EBP Compendium: Summary of Systematic Review

Auditory Neuropathy: Endocochlear Lesion or Temporal Processing Impairment? Implications for Diagnosis and Management

Vlastarakos, P. V., Nikolopoulos, T. P., et al. (2008).
International Journal of Pediatric Otorhinolaryngology, 72(8), 1135-1150.

Indicators of Review Quality:

The review addresses a clearly focused question No
Criteria for inclusion of studies are provided No
Search strategy is described in sufficient detail for replication Yes*
Included studies are assessed for study quality Yes*
Quality assessments are reproducible No

Description: This is a systematic review of studies investigating the assessment and intervention strategies for individuals with auditory neuropathy/dys-synchrony (AN/AD).

Question(s) Addressed:

  1.  What are the, "techniques that have been used in the diagnosis of AN/AD in the pediatric population?" (p. 1136).
  2. What is the, "efficacy of different modalities in the management of AN/AD?" (p. 1136).

Population: Individuals with auditory neuropathy/auditory dys-synchrony (AN/AD)

Intervention/Assessment: Assessments of AN/AD (includes OAEs, CMs, pure-tone audiometry, ABRs) and interventions for AN/AD (includes hearing aids and cochlear implants).

Number of Studies Included: 115

Years Included: Not stated



AN/AD should be considered in the diagnosis of hearing impaired children, especially children with neonatal risk factors. Diagnosis should consist of OAEs, CMs, ABRs, audiometry, and possibly genetic testing. Treatment for AN/AD should be individualized and timely.

Keywords: Auditory Neuropathy

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* Includes keywords and states one database searched (Medline) but indicates that others were searched without listing the databases.

*Includes evidence grades based on study design hierarchy, but does not assess quality of individual studies or provide data on all accepted studies.

Added to Compendium: December 2011

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