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EBP Compendium: Summary of Systematic Review

National Institute on Deafness and Other Communication Disorders, National Institutes of Health
Dependence of Hearing Changes on the Dose of Intratympanically Applied Gentamicin: A Meta-Analysis Using Mathematical Simulations of Clinical Drug Delivery Protocols

Salt, A. N., Gill, R. M., et al. (2008).
Laryngoscope, 118(10), 1793-1800.

Indicators of Review Quality:

The review addresses a clearly focused question No
Criteria for inclusion of studies are provided Yes
Search strategy is described in sufficient detail for replication No
Included studies are assessed for study quality No
Quality assessments are reproducible N/A

Description: This is a meta-analysis of studies investigating safe dosages of intratympanic gentamicin that can be used in individuals being treated for Meniere's disease without resulting ototoxicicity.

Question(s) Addressed:

Question not specifically stated.

Population: Not stated

Intervention/Assessment: Not applicable.

Number of Studies Included: 19

Years Included: Not further specified.



"...[T]here appears no logical rationale for rapidly repeated or continuous applications of gentamicin in the treatment of Meniere's disease." (p.1798)

Keywords: Ototoxicity, Hearing Loss

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Added to Compendium: December 2011

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